Praha 6 (safety 88, transport 85, night 32) versus Praha 7 (safety 80, transport 90, night 40) shows an 8-point safety advantage traded for 5 points better transport and marginally higher night scores. Praha 19 (safety 85, transport 60, night 35) sits between them on safety but falls significantly behind on connectivity, making it suitable only for visitors with cars or specific reasons to stay in the northern periphery.
Praha 6's #1 ranking comes at the cost of being further from Prague's cultural center and nightlife, while Praha 7 places you in the middle of the city's trendiest zone with superior metro access. The transport difference (85 vs 90) means Praha 7 connects to 2-3 additional metro lines and tram routes within walking distance, which compounds in convenience over a multi-day stay.
Check the specific metro line serving your shortlisted accommodation in each district, since Prague's transport quality varies dramatically by neighborhood despite high average scores. A flat in Praha 6 near Hradčanská metro provides completely different access than one requiring a bus transfer, and that difference matters more than a 5-point safety variation when pickpocketing is your primary risk rather than violent crime.